Recently, Lacto-N-neotetraose (LNnT), independently developed by Zhuhai Longjian Biotechnology Co., Ltd., has passed the review of the National Medical Products Administration (NMPA) and obtained the filing certificate for new domestic cosmetic raw materials (Filing No.: Guozhuang Yuanbei Zi 20260102). This marks that Longjian’s HMOs have achieved compliant layout across both food and cosmetic sectors. Leveraging domestic synthetic biotechnology, the company unlocks new skincare value of human milk oligosaccharides.
1. Official Authoritative Certification: Domestic HMOs Secures Another Compliant Qualification
Unlike general daily chemical raw materials, the filing of new cosmetic raw materials requires rigorous review of comprehensive documents including full toxicological safety assessments, action mechanisms, usage limits and quality standards. Only raw materials fully verified to be safe and effective can be approved for registration and public disclosure, which serves as a mandatory compliance threshold for raw materials entering the skincare market.
The publicly available filing information is sourced from the official NMPA data inquiry platform. The filing applicant is Zhuhai Longjian Biotechnology Co., Ltd., a local Chinese enterprise. The LNnT raw material is entirely self-developed and domestically manufactured, representing a truly home-grown HMOs product that fully advances the domestic substitution of synthetic biomaterials. With the public filing effective June 12, 2026, LNnT is now legally permitted for use in the production of all types of cosmetics.
2. From Infant Formula to Skincare: Unlocking Versatile Application Potential of LNnT
Lacto-N-neotetraose (LNnT) is a core component of human milk oligosaccharides (HMOs). It has long been widely and maturely applied in infant formula milk powder, protecting maternal and infant health with its human-compatible and mild repairing natural properties.
Now empowered by Longjian Bio’s core synthetic biotechnology, LNnT breaks its original application boundaries and gains approval as a new cosmetic raw material. It can be extensively incorporated into all categories of skincare products, such as repairing serums, soothing facial masks, anti-aging creams and sensitive skin care items. Covering both maternal-infant nutrition and skin care markets, HMOs bring the natural active power derived from human milk to satisfy people’s diverse health demands.
3. Dual-Track Qualifications Strengthen Longjian Bio’s Core Competitive Moat
As one of the few synthetic biotech enterprises in China holding complete filing qualifications for both food-grade and cosmetic-grade LNnT, the newly obtained cosmetic raw material filing further improves the company’s full-scenario compliance system and reinforces its core technological strengths in independent R&D and multi-sector applications:
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Dual-sector compliance edge: The full HMOs product line connects the food and daily chemical markets, delivering one-stop raw material supply solutions for clients engaged in infant formula, functional food and beauty skincare to support diversified business layouts.
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Domestic self-developed technological barrier: Relying on its proprietary synthetic biological fermentation platform, all production processes are localized, eliminating reliance on overseas raw material supplies with stable and controllable delivery to help upstream and downstream brands realize raw material localization upgrading.
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Authoritative compliance endorsement: The official NMPA filing record acts as core compliance certification for beauty brands and OEM factories purchasing raw materials. It can be directly used for brand promotion, exhibition displays and qualification labeling on product packaging, greatly boosting the credibility of end consumer products.
4. Empowering the Health Industry Through Synthetic Biotechnology
Since its entry into the human milk oligosaccharide sector, Longjian Bio has consistently adhered to independent innovation, developing high-purity and high-activity HMOs raw materials via synthetic biological technology. From 2'-FL to LNnT, from nutritional food to skin care, the enterprise keeps exploring the diversified value of active ingredients extracted from human milk.
The successful filing of LNnT as a new cosmetic raw material stands not only as a milestone for the company, but also a major breakthrough for the domestic HMOs industry. Moving forward, Longjian Bio will continuously expand its full-range HMOs raw material portfolio and advance multi-sector development covering food, cosmetics and special dietary foods. With home-grown scientific innovation, the enterprise will supply safe, premium and mass-producible bioactive raw materials for the broader health industry.
